In addition, also other tumors such as thymic neuroendocrine tumors (TNET) associate with MEN1. The classical manifestations of the syndrome are primary hyperparathyroidism (PHPT), pituitary adenomas, and pancreatic (PNET) and duodenal (DNET) neuroendocrine tumors. Multiple endocrine neoplasia type 1 (MEN1) is an inherited autosomal dominant tumor-predisposing syndrome caused by inactivating mutations of the MEN1 gene, which is located on chromosome 11q13 and encodes the 610 amino acid protein menin. We also show that LCNEC can be associated with TNET in MEN1 patients. The prognosis can be better by systematic screening. TNET in MEN1 patients is an aggressive disease. In this study, TNETs were observed in one large MEN1 founder pedigree, where an anticipation-like earlier disease onset was observed in the most recent generation. In our patients, the 5-year survival of the TNET patients was 62.5% and 10-year survival 31.3%. One patient had a largely necrotic main tumor with very few mitoses and another nodule with 25 mitoses per 2 mm 2, qualifying for the 2021 WHO diagnosis of large cell neuroendocrine carcinoma (LCNEC). TNET was classified as atypical carcinoid (AC) in five out of six patients. ![]() The mean age at presentation of TNET was 44.7 ± 11.9 years. They originated from common ancestors encompassing two pairs of brothers from sequential generations. Five of them had the same common gene mutation occurring in Finland. There were six patients (3.3%) with MEN1 and TNET. We collected data on treatments and outcomes of these patients. ![]() Thymus tumor specimens were classified according to the new WHO 2021 classification of TNET. We evaluated patient records of 183 MEN1-patients from three university hospitals between the years 1985–2019 with TNETs. We evaluated patients with MEN1 and TNET in three university hospitals in Finland. Neuroendocrine tumors of the thymus (TNETs) are very rare but often have an aggressive nature. This album is dedicated to the music giants Maurice White, David Bowie and Prince whose legacy will live on.MEN1 is associated with an increased risk of developing tumors in different endocrine organs. * God for the love, guidance and for answering my prayers * My brother Mika for the third pair of ears * Our lovely daughters Alina and Elsa for the inspiration * My loving wife Kirsi for your love, courage, support and patience * The late great M1 studio for letting me use their Hammond A100 organ * Anja and Markku Muhonen for the catering * Heikki Kynsijärvi and Joni Laitinen for the video production ![]() * Markus Ketola for the great sound, vision and patience * Iina-Maria Aalto & Pauliina Seppälä at * Jonnu Heikkilä for the wonderful lyrics! You have a gift and ability to read my mind * A big thank you to MES (Musiikinedistämissäätiö) * Thank you all the musicians, who played on the album or who have played on our gigs: Janne Halonen, Sampo Tiittanen, Jonatan Sarikoski, William Suvanne, Janne Toivonen, Ilmari Pohjola, Timo Rantanen, Jepa Lambert, Heini Ikonen, Hanna-Maria Helenius, Jonnu Heikkilä, Joakim Berghäll, Antti Rissanen, Linda Fredriksson, Teemu Mattsson, Toni Porthén, Ossi Maristo, Onni Lonka, Mikko Kaakkuriniemi and Juha Räsänen. Tanhua, Tero Tilus, Karla-Maria & Panu Toiviainen, Heikki Topi, Riitta & Raimo Tuomala and Rainer Wahlsten. A big THANK YOU to all the funders, especially Maiju Ahlholm, Lauri Aho, Esa Ahonen, Rauno Berg, Katja Erkoma, Elina Eteläaho, Erika Hallamaa, Airi Helin, Anneli Helin-Pettinen, Olli Jaakkola, Sami Kaivosoja, Mikko Kangas, Jouko Kantola, Kyösti Kemppi, Miika Kännälä, Aki Laapio, Elisa Malmi, Pentti Martiskainen, Kari-Pekka Nyyssönen, Tapio Piili, Kirsi Rouhiainen, Ville Savolainen, Petri Takala, E. * This album was funded mostly by the -crowdfunding campaign. Mikko Pettinen: lead vocals, Rhodes piano, Nord Electro, Hammond A100, trumpet (A1, B1), flugelhorn (B3) Recorded live at UMO Jazz Orchestra´s facilities at YLE´s radio house between October 31st and November 1st 2015.
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